EC Biodelivery^TM Platform

The EC Biodelivery^TM platform is a general biodelivery system of cell-derived substances to the Central Nervous System (CNS) that provides a controlled, site-specific and safe delivery of a variety of therapeutic substances. For CNS indications one or multiple EC Biodelivery^TM devices can be implanted in defined regions of the brain to deliver any proteins or neurotransmitters across the blood-brain-barrier. The proprietary EC Biodelivery^TM system consists of a catheter-like device that in the active portion contains a genetically modified human cell line enclosed behind a semi-permeable hollow fiber membrane. The membrane allows for the influx of nutrients and outflow of the therapeutic factor(s) but does not allow for the direct contact between the therapeutic cells and the host tissue. The encapsulated cells provide for long-term (> 12 months) factor secretion from the implanted device.  

EC Biodelivery^TM is a strongly and broadly patented technology platform that offers great safety advantages over direct gene therapy approaches and technical and functional advantages over pump technologies. The device is compatible with stereotactic neurosurgical techniques and instrumentation adapters to common stereotactic frames have been made. EC Biodelivery^TM devices are suitable for intraparenchymal, intracerebroventricular, or intrathecal placement.