Factor Pipeline

The NsGene factor pipeline has been generated in the collaboration with DTU and represents a unique list of novel growth factors or hormones that have not been well characterized for their biological functions. Additional characterization is ongoing on selected factors in academic collaborations but the Company is looking for additional collaborations or partnerships to realize the full potential and value of these therapeutically interesting secreted factors.

ID	Factor description	Expression
NsG3	212 amino acid secreted human growth factor. Member of the TGF-beta super family	Ubiquitously expressed. NsG3 shows distinct effect on survival of hippocampal slice cultures in the presence of NMDA
NsG6	98 amino acid pro-hormone processed into several putative peptide hormones	Expression of NsG6 is testis specific and under developmental regulation. Highest expression in adult testis.
NsG25	385 (a) and 269 (b) aa secreted isoforms functionally predicted to be involved in immune response (a) and growth factor action (b)	Highly expressed in CNS and testis and developmentally regulated in putamen and nigra
NsG28-32	A family of 5 secreted growth factors with 10 well-conserved cysteine residues (Cys10-family). This family shows high homology to orthologues in numerous organisms.	Expression of CYS10 transcripts is CNS Specific and highly regulated during development of putamen and nigra (All), dorsal mesencephalon and spinal cord (NsG29), cerebellum and cortex (NsG29, NsG30 and NsG32).
NsG35	430 amino acid secreted human growth factor. Highly conserved between species (97 % identical to mouse).	NsG35 is CNS specific and expression is regulated during development of putamen and nigra. GEO profiles indicate that NsG35 is upregulated in Huntington’s patients.
NsG39	229 amino acid human growth factor with predicted signal peptide. This protein is extremely well-conserved across species with all cysteines (15) fully conserved in rodent, pan troglodytes and bos taurus.	NsG39 is highly expressed in all human tissues and shows upregulation in putamen and nigra during development of mouse CNS. The 5’ end of NsG39 maps to a highly complex disease locus (spinocerebellar ataxia, diabetes II, amyotrophy, neuronopathy and schizophrenia).
NsG40	208 amino acid human protein with predicted signal peptide and a propeptide cleavage site. The protein is highly conserved between species with conservation of all cysteine residues.	NsG40 is highly expressed in all human tissues, highest in kidney. NsG40 is not expressed during development of mouse CNS but is highly expressed in adult cortex, nigra, putamen, cerebellum and spinal cord.
NsG41	278 amino acid secreted human growth factor. NsG41 is well-conserved across species.	NsG41 is highly expressed in most human tissues.
NsG42	242 amino acid human growth factor with predicted signal peptide. NsG42 is relatively well-conserved across vertebrate species.	NsG42 is highly expressed in human retina, ganglion, spleen and adult CNS. NsG42 is not expressed during development of mouse CNS but is highly expressed in adult cortex, nigra, putamen, cerebellum and spinal cord.
NsG46	NsG46 is homologues to NsG35 (30%) with 11/16 conserved cysteine residues.	Expression is high in placenta, uterus, ovary and certain CNS tissues.