EC BiodeliveryTM Platform
In order to apply potent therapeutic protein factors to the Central Nervous System (CNS), it has become evident that direct brain delivery of a relevant factor in a distinct anatomical area is necessary to achieve therapeutic effects. Local cell-based delivery of a neurotrophic factor has thus formed a clear product concept for NsGene. NsGene’s proprietary Encapsulated Cell (EC) biodeliveryTM system combines the efficacy of local synthesis and delivery with the safety and manufacturability of a medical device.
The EC BiodeliveryTM platform provides a controlled, site-specific and safe delivery of a variety of therapeutic substances. For CNS indications, one or multiple EC BiodeliveryTM devices can be implanted in defined regions of the brain to deliver any proteins or neurotransmitters across the blood-brain barrier. The EC BiodeliveryTM system consists of a catheter-like device that in the active portion contains a genetically modified human cell line enclosed behind a semi-permeable hollow fiber membrane. The membrane allows for the influx of nutrients and outflow of the therapeutic factor(s) and prevents direct contact between the therapeutic cells and the host tissue. The encapsulated cells provide for long-term (> 12 months) factor secretion from the implanted device.
EC BiodeliveryTM is a strongly and broadly patented technology platform that offers great safety advantages over direct gene therapy approaches and technical and functional advantages over pump technologies. The device is compatible with stereotactic neurosurgical techniques and instrumentation adapters to common stereotactic frames have been made. EC BiodeliveryTM devices are suitable for intraparenchymal, intracerebroventricular, or intrathecal placement.
Based on the EC biodeliveryTM technology, NsGene develops EC BiodeliveryTM products for neurological diseases including Alzheimer’s disease (NsG0202), and Parkinson’s disease. Furthermore, the EC BiodeliveryTM technology is a versatile platform for local delivery of numerous other biological molecules such as proteins, peptides, antibodies and neurotransmitters across the blood-brain barrier.
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